A Scientific Foundation

An impressive portfolio of academic publications

A Scientific Foundation

The company has successfully secured two patent families and is awaiting the approval of three additional patent applications.

Furthermore, it boasts an impressive portfolio of academic publications that delve into the application of CAPOSAL® technology in the dental field, demonstrating its commitment to research and innovation:

  • Unosson, E.; Feldt, D.; Xia, W.; Engqvist, H. Amorphous Calcium Magnesium Fluoride Phosphate—Novel Material for Mineralization in Preventive Dentistry. Appl. Sci. 2023, 13, 6298. https://doi.org/10.3390/app13106298
  • Berg, C.; Unosson, E.; Engqvist, H.; Xia, W. Comparative Study of Technologies for Tubule Occlusion and Treatment of Dentin Hypersensitivity. J. Funct. Biomater. 2021, 12, 27. https://doi.org/10.3390/jfb12020027
  • Berg, C.; Unosson, E.; Engqvist, H.; Xia, W. Amorphous Calcium Magnesium Phosphate Particles for Treatment of Dentin Hypersensitivity: A Mode of Action Study. ACS Biomater. Sci. Eng. 2020, 6, 6, 3599–3607. https://doi.org/10.1021/acsbiomaterials.0c00262
  • Berg, C.; Unosson, E.; Riekehr, L.; Xia, W.; Engqvist, H. Electron microscopy evaluation of mineralization on peritubular dentin with amorphous calcium magnesium phosphate microspheres. Ceram. Int. 2020, 46, 11, B, 19469-19475. https://doi.org/10.1016/j.ceramint.2020.04.295
  • Mellgren, T.; Qin, T.; Öhman-Mägi, C.; Zhang, Y.; Wu, B.; Xia, W.; Engqvist, H. Calcium Phosphate Microspheres as a Delivery Vehicle for Tooth-Bleaching Agents. J. Dent. Res. 2018, 97, 3, 283–288. https://doi.org/10.1177/0022034517741295
  • Qin, T.; Mellgren, T.; Jefferies, S.; Xia, W.; Engqvist, H. A Study for Tooth Bleaching via Carbamide Peroxide-Loaded Hollow Calcium Phosphate Spheres. Dent. J. 2017, 5, 3. https://doi.org/10.3390/dj5010003
  • Xia, W.; Qin, T.; Suska, F.; Engqvist, H. Bioactive Spheres: The Way of Treating Dentin Hypersensitivity. ACS Biomater. Sci. Eng. 2016, 2, 5, 734-740. https://doi.org/10.1021/acsbiomaterials.5b00499

Examples of other articles for non-dental applications of CAPOSAL®:

  • Li, H.; Edin, F.; Hayashi, H.; Gudjonsson, O.; Danckwardt-Lillieström, N.; Engqvist, H.; Rask-Andersen, H.; Xia, W. Guided Growth of Auditory Neurons: Bioactive Particles Towards Gapless Neural – Electrode Interface. Biomaterials, 122: 1-9 2017. https://doi.org/10.1016/j.biomaterials.2016.12.020
  • Garbani, M.; Xia, W.; Rhyner, C.; Prati, M.; Scheynius, A.; Malissen, B.; Engqvist, H.; Maurer, M.; Crameri, R.; Terhorst, D. Allergen-Loaded Strontium-Doped Hydroxyapatite Spheres Improve Allergen-Specific Immunotherapy in Mice. Journal of Investigative Dermatology, 136(9): S225-S225 2016. https://doi.org/10.1111/all.13041
  • Qin, T.; López, A.; Öhman, C.; Engqvist, H.; Persson, C.; Xia, W. Enhanced Drug Delivery of Antibiotic-Loaded Acrylic Bone Cements Using Calcium Phosphate Spheres. Journal of Applied Biomaterials & Functional Materials, 13(3): E241-E247 2015. https://doi.org/10.5301/jabfm.5000222
  • Cardemil, C.; Elgali, I.; Xia, W.; Emanuelsson, L.; Norlindh, B.;,Omar, O.;,Thomsen, P. Strontium-Doped Calcium Phosphate and Hydroxyapatite Granules Promote Different Inflammatory and Bone Remodelling Responses in Normal and Ovariectomised Rats. PLOS ONE, 8(12): e84932- 2013. https://doi.org/10.1371/journal.pone.0084932
  • Hulsart-Billström, G.; Xia, W.; Pankotai, E.; Weszl, M.; Carlsson, E.; Forster-Horváth, C.; Larsson, S.; Engqvist, H.; Lacza, Z. Osteogenic Potential of Sr-Doped Calcium Phosphate Hollow Spheres In Vitro and In Vivo. Journal of Biomedical Materials Research. Part A, 101(8): 2322-2331 2013. https://doi.org/10.1002/jbm.a.34526
  • Xia, W.; Grandfield, K.; Schwenke, A.; Engqvist, H. Synthesis and Release of Trace Elements from Hollow and Porous Hydroxyapatite Spheres. Nanotechnology, Volume 22, Number 30 2011 https://doi.org/10.1088/0957-4484/22/30/305610